Toxicological Considerations, Toxicity Assessment, and Risk Management of Inhaled Nanoparticles
نویسندگان
چکیده
منابع مشابه
Toxicological Considerations, Toxicity Assessment, and Risk Management of Inhaled Nanoparticles
Novel engineered nanoparticles (NPs), nanomaterial (NM) products and composites, are continually emerging worldwide. Many potential benefits are expected from their commercial applications; however, these benefits should always be balanced against risks. Potential toxic effects of NM exposure have been highlighted, but, as there is a lack of understanding about potential interactions of nanomat...
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The key unanswered question in the particulate matter (PM)related health concern is the biological plausibility of the association between PM and the observed adverse cardiopulmonary health effects. These adverse health outcomes have been demonstrated by both cross-sectional and time-series epidemiological studies. Key to the validity of the biological plausibility is the need to identify the c...
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Viral infections can cause of death in humans worldwide, despite the tremendous progress in human medicine. Particle size is a very important physical characteristic that can affect bioavailability and circulation time of nanoparticles. The ratio of large surface area and volume of nanoparticle enhanced solubility of poorly soluble drug compounds, optimum surface charge of the nanoparticle wi...
متن کاملApplying Nanoparticles in the Treatment of Viral Infections and Toxicological Considerations
Background: Despite the tremendous progress in human medicine, viral infections can cause death in them. Due to the high prevalence of viruses, it is required to develop novel treatment strategies and provide the site-specific delivery of antiviral agents at the viral reservoirs. Objectives: Particle size is a vital physical characteristic that can affect the bioavailability and circulation ti...
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The alveolar epithelium of the lung is by far the most permeable epithelial barrier of the human body. The risk for adverse effects by inhaled nanoparticles (NPs) depends on their hazard (negative action on cells and organism) and on exposure (concentration in the inhaled air and pattern of deposition in the lung). With the development of advanced in vitro models, not only in vivo, but also cel...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2016
ISSN: 1422-0067
DOI: 10.3390/ijms17060929